Für die Studierenden im 4. Semester bieten wir - in Zusammenarbeit mit zahlreichen Kollegen - die „Einführung in die klinische Medizin“ an. Mit dieser Veranstaltung möchten wir die Studierenden auf den klinischen Alltag vorbereiten und die Grundlagen für evidenzbasierte Entscheidungen und evidenzbasiertes Handeln vermitteln.

In der Präsenz-Blockveranstaltung an zwei Tagen jeweils zu Beginn des Sommersemesters werden die Studierenden in einer Mischung aus Impulsvorträgen und Kleingruppenarbeit mit der Wissenschaft im ärztlichen Alltag und der Ethik in der Wissenschaft vertraut gemacht, sie lernen die Grundlagen der Literaturrecherche und der Statistik in der klinischen Forschung kennen und lernen, wissenschaftliche Arbeiten zu  beurteilen und Verzerrungen im wissenschaftlichen Research Reporting zu erkennen.

In den folgenden zwei Wochen werden sie im Rahmen einer kurzen schriftlichen Hausarbeit eine wissenschaftliche Fragestellung formulieren und sich mit den klassischen Studiendesigns auseinandersetzen. Im Anschluss daran werden sie beim peer-review der Hausarbeit von Kommilitonen das schriftliche Feed-Back-Geben üben.

Die letzte Pflicht für den Scheinerhalt ist eine kurze Abschlussveranstaltung im Mai.

Für die Studierenden im 5. Semester des Bachelor Studiengangs MBT bieten wir die VL „Klinische Immunologie“ an, die immer im WiSe, an 7 Donnerstagen vor Weihnachten, jeweils von 10:15 – 11:45 Uhr, im HS ZIM stattfindet. Inhalte und Lernziele der VL, sowie der Zugriff auf die VL-Folien werden zu Beginn des Semesters bekannt gegeben.
Bei Fragen zur Veranstaltung wenden Sie sich bitte an Frau Professor Müller-Hilke (brigitte.mueller-hilke{bei}med.uni-rostock.de) oder 494/5833.

Für die Studierenden im 3. Semester des Master Studiengangs MBT wird das Modul „moderne molekulare und Hochdurchsatz-Technologien in der medizinischen Grundlagenforschung“ angeboten. Das Modul besteht für jeden Studierenden aus 10 Tagen Praktikum, die bereits vor dem Semesterbeginn beginnen. Die Gruppeneinteilung wird elektronisch vorgenommen. Zu dem Modul gehören im laufenden WS je eine Stunde Seminar und eine Stunde VL, über die Sie zum Semesterbeginn informiert werden.
Bei Fragen zur Veranstaltung wenden Sie sich bitte an Frau Professor Müller-Hilke (brigitte.mueller-hilke{bei}med.uni-rostock.de) oder 494/5833.

Schriftenverzeichnis Prof. Dr. rer. nat. Müller-Hilke, MME:

Kayser A, Wolff A, Berlin P, Duehring L, Henze L, Mundkowski R, Bergmann W, Müller-Hilke B, Wagner C, Huehns M, Oehmcke-Hecht S, Maletzki C. 2024. Selective but not pan-CDK inhibition abrogates 5-FU-driven tissue factor upregulation in colon cancer. Sci Rep 14:10582. doi:10.1038/s41598-024-61076-5.

Mai F, Bergmann W, Reisinger EC, Müller-Hilke B. 2024. The varying extent of humoral and cellular immune responses to either vector- or RNA-based SARS-CoV-2 vaccines persists for at least 18 months and is independent of infection. J Virol 98:e0191223. doi:10.1128/jvi.01912-23.

Mai F, Kordt M, Bergmann-Ewert W, Reisinger EC, Müller-Hilke B. 2024. NVX-CoV2373 induces humoral and cellular immune responses that are functionally comparable to vector and mRNA-based vaccines. Front Immunol 15:1359475. doi:10.3389/fimmu.2024.1359475.

Müller-Hilke B, Finger C, Hampe W. 2024. Neues Zulassungsverfahren Humanmedizin: höhere individuelle Gerechtigkeit, aber Verstärkung des Landarztmangels? Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 67:225–232. doi:10.1007/s00103-023-03825-x.

Bischofsberger M, Reinholdt C, Dannenhaus TA, Aleith J, Bergmann-Ewert W, Müller-Hilke B, Löbermann M, Reisinger EC, Sombetzki M. 2023. Individually or as a Team-The Immunological Milieu in the Lung Caused by Migrating Single-Sex or Mixed-Sex Larvae of Schistosoma mansoni. Pathogens 12. doi:10.3390/pathogens12121432.

Lorenz P, Steinbeck F, Mai F, Reisinger EC, Müller-Hilke B. 2023. A linear B-cell epitope close to the furin cleavage site within the S1 domain of SARS-CoV-2 Spike protein discriminates the humoral immune response of nucleic acid- and protein-based vaccine cohorts. Front Immunol 14:1192395. doi:10.3389/fimmu.2023.1192395.

Revskij D, Runst J, Umstätter C, Ehlers L, Rohde S, Zechner D, Bastian M, Müller-Hilke B, Fuellen G, Henze L, Murua Escobar H, Junghanss C, Kowald A, Walter U, Köhling R, Wolkenhauer O, Jaster R. 2023. Uncoupling protein 2 deficiency of non-cancerous tissues inhibits the progression of pancreatic cancer in mice. Hepatobiliary Pancreat Dis Int 22:190–199. doi:10.1016/j.hbpd.2022.12.003.

Stratos I, Rinas I, Schröpfer K, Hink K, Herlyn P, Bäumler M, Histing T, Bruhn S, Müller-Hilke B, Menger MD, Vollmar B, Mittlmeier T. 2023. Effects on Bone and Muscle upon Treadmill Interval Training in Hypogonadal Male Rats. Biomedicines 11. doi:10.3390/biomedicines11051370.

Vasudevan P, Wolfien M, Lemcke H, Lang CI, Skorska A, Gaebel R, Galow A-M, Koczan D, Lindner T, Bergmann W, Mueller-Hilke B, Vollmar B, Krause BJ, Wolkenhauer O, Steinhoff G, David R. 2023. CCR2 macrophage response determines the functional outcome following cardiomyocyte transplantation. Genome Med 15:61. doi:10.1186/s13073-023-01213-3.

Aleith J, Brendel M, Weipert E, Müller M, Schultz D, Ko-Infekt SG, Müller-Hilke B. 2022. Influenza A Virus Exacerbates Group A Streptococcus Infection and Thwarts Anti-Bacterial Inflammatory Responses in Murine Macrophages. Pathogens 11. doi:10.3390/pathogens11111320.

Mai F, Volzke J, Reisinger EC, Müller-Hilke B. 2022. Vaccine-Induced T-Cell and Antibody Responses at 12 Months after Full Vaccination Differ with Respect to Omicron Recognition. Vaccines (Basel) 10. doi:10.3390/vaccines10091563.

Massing T, Will K, Müller M, Aleith J, Lindner T, Warkentin M, Müller-Hilke B, Mittlmeier T. 2022. Prolonged treadmill training is not able to prevent ovariectomy-induced bone loss. Front Physiol 13:1078857. doi:10.3389/fphys.2022.1078857.

Müller M, Volzke J, Subin B, Müller S, Sombetzki M, Reisinger EC, Müller-Hilke B. 2022. Single-dose SARS-CoV-2 vaccinations with either BNT162b2 or AZD1222 induce disparate Th1 responses and IgA production. BMC Med 20:29. doi:10.1186/s12916-022-02240-4.

Müller M, Volzke J, Subin B, Schmidt CJ, Geerdes-Fenge H, Reisinger EC, Müller-Hilke B. 2022. Distinguishing Incubation and Acute Disease Stages of Mild-to-Moderate COVID-19. Viruses 14. doi:10.3390/v14020203.

Müller-Hilke B, Mai F, Müller M, Volzke J, Reisinger EC. 2022. Higher SARS-CoV-2 Spike Binding Antibody Levels and Neutralization Capacity 6 Months after Heterologous Vaccination with AZD1222 and BNT162b2. Vaccines (Basel) 10. doi:10.3390/vaccines10020322.

Oehmcke-Hecht S, Berlin P, Müller-Hilke B, Kreikemeyer B, Vasudevan P, Henze L, Khaimov V, Vollmar B, David R, Maletzki C. 2022. The versatile role of the contact system in cardiovascular disease, inflammation, sepsis and cancer. Biomed Pharmacother 145:112429. doi:10.1016/j.biopha.2021.112429.

Ebbers M, Hemmer CJ, Müller-Hilke B, Reisinger EC. 2021. Immunotherapy and vaccination against infectious diseases. Wien Klin Wochenschr 133:714–720. doi:10.1007/s00508-020-01746-2.

Hogh A, Müller-Hilke B. 2021. Learning strategies and their correlation with academic success in biology and physiology examinations during the preclinical years of medical school. PLoS One 16:e0245851. doi:10.1371/journal.pone.0245851.

Kaddatz H, Joost S, Nedelcu J, Chrzanowski U, Schmitz C, Gingele S, Gudi V, Stangel M, Zhan J, Santrau E, Greiner T, Frenz J, Müller-Hilke B, Müller M, Amor S, van der Valk P, Kipp M. 2021. Cuprizone-induced demyelination triggers a CD8-pronounced T cell recruitment. Glia 69:925–942. doi:10.1002/glia.23937.

Lampe LC, Müller-Hilke B. 2021. Mindfulness-based intervention helps preclinical medical students to contain stress, maintain mindfulness and improve academic success. BMC Med Educ 21:145. doi:10.1186/s12909-021-02578-y.

Volzke J, Müller-Hilke B. 2021. Degenerative Joint Damage Is Not a Risk Factor for Streptococcal Sepsis and Septic Arthritis in Mice. Life (Basel) 11. doi:10.3390/life11080794.

Boeckmann L, Schäfer M, Bernhardt T, Semmler ML, Jung O, Ojak G, Fischer T, Peters K, Nebe B, Müller-Hilke B, Seebauer C, Bekeschus S, Emmert S. 2020. Cold Atmospheric Pressure Plasma in Wound Healing and Cancer Treatment. Applied Sciences 10:6898. doi:10.3390/app10196898.

Buschhart A-L, Bolten L, Volzke J, Ekat K, Kneitz S, Mikkat S, Kreikemeyer B, Müller-Hilke B. 2020. Periodontal pathogens alter the synovial proteome. Periodontal pathogens do not exacerbate macroscopic arthritis but alter the synovial proteome in mice. PLoS One 15:e0242868. doi:10.1371/journal.pone.0242868.

Kaufmann S, Glass Ä, Kropp P, Müller-Hilke B. 2020. Semantic fluency including task switching predicts academic success in medical school. PLoS One 15:e0244456. doi:10.1371/journal.pone.0244456.

Latza J, Otte M, Lindner T, Fischer D-C, Bruhn S, Hollinski R, Warkentin M, Mittlmeier T, Müller-Hilke B. 2020. Interval Training Is Not Superior to Endurance Training With Respect to Bone Accrual of Ovariectomized Mice. Front Physiol 11:1096. doi:10.3389/fphys.2020.01096.

Loeffler H, Jonitz-Heincke A, Peters K, Mueller-Hilke B, Fiedler T, Bader R, Klinder A. 2020. Comparison of Inflammatory Effects in THP-1 Monocytes and Macrophages after Exposure to Metal Ions. Materials (Basel) 13. doi:10.3390/ma13051150.

Schmidt CJ, Wenndorf K, Ebbers M, Volzke J, Müller M, Strübing J, Kriebel K, Kneitz S, Kreikemeyer B, Müller-Hilke B. 2020. Infection With Clostridioides difficile Attenuated Collagen-Induced Arthritis in Mice and Involved Mesenteric Treg and Th2 Polarization. Front Immunol 11:571049. doi:10.3389/fimmu.2020.571049.

Schultz D, Surabhi S, Stelling N, Rothe M, Group KoInfekt Study, Methling K, Hammerschmidt S, Siemens N, Lalk M. 2020. 16HBE Cell Lipid Mediator Responses to Mono and Co-Infections with Respiratory Pathogens. Metabolites 10. doi:10.3390/metabo10030113.

Volzke J, Schultz D, Kordt M, Müller M, Bergmann W, Methling K, Kreikemeyer B, Müller-Hilke B. 2020. Inflammatory Joint Disease Is a Risk Factor for Streptococcal Sepsis and Septic Arthritis in Mice. Front Immunol 11:579475. doi:10.3389/fimmu.2020.579475.

Cipra C, Müller-Hilke B. 2019. Testing anxiety in undergraduate medical students and its correlation with different learning approaches. PLoS One 14:e0210130. doi:10.1371/journal.pone.0210130.

Dohr D, Engelmann R, Müller-Hilke B. 2019. A novel method to efficiently isolate medullary thymic epithelial cells from murine thymi based on UEA-1 MicroBeads. J Immunol Methods 467:12–18. doi:10.1016/j.jim.2019.02.001.

Gebhard A, Müller-Hilke B. 2019. Criteria of medical students for the selection of their future clinical specialisation: a cross-sectional survey at the Medical Faculty of Rostock. GMS J Med Educ 36:Doc76. doi:10.3205/zma001284.

Herbst CV, Müller-Hilke B. 2019. Motivation as an important criterion for graduation among medical students admitted from the waiting list. GMS J Med Educ 36:Doc6. doi:10.3205/zma001214.

Jonitz-Heincke A, Sellin M-L, Seyfarth A, Peters K, Mueller-Hilke B, Fiedler T, Bader R, Klinder A. 2019. Analysis of Cellular Activity Short-Term Exposure to Cobalt and Chromium Ions in Mature Human Osteoblasts. Materials (Basel) 12. doi:10.3390/ma12172771.

Lübcke PM, Ebbers MNB, Volzke J, Bull J, Kneitz S, Engelmann R, Lang H, Kreikemeyer B, Müller-Hilke B. 2019. Periodontal treatment prevents arthritis in mice and methotrexate ameliorates periodontal bone loss. Sci Rep 9:8128. doi:10.1038/s41598-019-44512-9.

Neßlauer A-M, Gläser A, Gräler M, Engelmann R, Müller-Hilke B, Frank M, Burstein C, Rolfs A, Neidhardt J, Wree A, Witt M, Bräuer AU. 2019. A therapy with miglustat, 2-hydroxypropyl-ß-cyclodextrin and allopregnanolone restores splenic cholesterol homeostasis in Niemann-pick disease type C1. Lipids Health Dis 18:146. doi:10.1186/s12944-019-1088-2.

Astfalk T, Müller-Hilke B. 2018. Same same but different - A qualitative study on the development and maintenance of personal networks among German and international medical students. GMS J Med Educ 35:Doc58. doi:10.3205/zma001204.

Ebbers M, Lübcke PM, Volzke J, Kriebel K, Hieke C, Engelmann R, Lang H, Kreikemeyer B, Müller-Hilke B. 2018. Interplay between P. gingivalis, F. nucleatum and A. actinomycetemcomitans in murine alveolar bone loss, arthritis onset and progression. Sci Rep 8:15129. doi:10.1038/s41598-018-33129-z.

Engelmann R, Biemelt A, Johl A, Kuthning D, Müller-Hilke B. 2018. Reduced Numbers of Mature Medullary Thymic Epithelial Cells in SKG Mice. Scand J Immunol 87:28–35. doi:10.1111/sji.12626.

Engelmann R, Nekarda S, Kuthning D, Kneitz C, Müller-Hilke B. 2018. Decreased IgG4 ACPA levels in responders and increased CD1c+ classical dendritic cells in non-responders of patients with rheumatoid arthritis under therapy. Clin Rheumatol 37:1783–1790. doi:10.1007/s10067-018-4053-y.

Hartjen N, Bräuer L, Reiß B, Claassen H, Beileke S, Garreis F, Hoogeboom S, Tsokos M, Etzold S, Müller-Hilke B, Gelse K, Müller T, Goldring MB, Paulsen F, Schicht M. 2018. Evaluation of surfactant proteins A, B, C, and D in articular cartilage, synovial membrane and synovial fluid of healthy as well as patients with osteoarthritis and rheumatoid arthritis. PLoS One 13:e0203502. doi:10.1371/journal.pone.0203502.

Hollinski R, Osterberg A, Polei S, Lindner T, Cantré D, Mittlmeier T, Vollmar B, Bruhn S, Müller-Hilke B. 2018. Young and healthy C57BL/6 J mice performing sprint interval training reveal gender- and site-specific changes to the cortical bone. Sci Rep 8:1529. doi:10.1038/s41598-018-19547-z.

Klopsch C, Skorska A, Ludwig M, Lemcke H, Maass G, Gaebel R, Beyer M, Lux C, Toelk A, Müller K, Maschmeier C, Rohde S, Mela P, Müller-Hilke B, Jockenhoevel S, Vollmar B, Jaster R, David R, Steinhoff G. 2018. Intramyocardial angiogenetic stem cells and epicardial erythropoietin save the acute ischemic heart. Dis Model Mech 11. doi:10.1242/dmm.033282.

Kriebel K, Hieke C, Engelmann R, Potempa J, Müller-Hilke B, Lang H, Kreikemeyer B. 2018. Porphyromonas gingivalis Peptidyl Arginine Deiminase Can Modulate Neutrophil Activity via Infection of Human Dental Stem Cells. J Innate Immun 10:264–278. doi:10.1159/000489020.

Kriebel K, Hieke C, Müller-Hilke B, Nakata M, Kreikemeyer B. 2018. Oral Biofilms from Symbiotic to Pathogenic Interactions and Associated Disease -Connection of Periodontitis and Rheumatic Arthritis by Peptidylarginine Deiminase. Front Microbiol 9:53. doi:10.3389/fmicb.2018.00053.

Kriesen U, Altiner A, Müller-Hilke B. 2018. Perception of bedside teaching within the palliative care setting-views from patients, students and staff members. Ann Palliat Med 7:411–419. doi:10.21037/apm.2018.05.01.

Osterberg A, Engelmann R, Müller-Hilke B. 2018. Allogeneic yet major histocompatibility complex-matched bone marrow transplantation in mice results in an impairment of osteoblasts and a significantly reduced trabecular bone. J Bone Miner Metab 36:420–430. doi:10.1007/s00774-017-0859-y.

Engelmann R, Müller-Hilke B. 2017. Experimental silicosis does not aggravate collagen-induced arthritis in mice. J Negat Results Biomed 16:5. doi:10.1186/s12952-017-0071-6.

Fritzsche C, Ghanem H, Koball S, Mueller-Hilke B, Reisinger EC. 2017. High Pneumocystis jirovecii colonization rate among haemodialysis patients. Infect Dis (Lond) 49:132–136. doi:10.1080/23744235.2016.1225980.

Hahn H, Kropp P, Kirschstein T, Rücker G, Müller-Hilke B. 2017. Test anxiety in medical school is unrelated to academic performance but correlates with an effort/reward imbalance. PLoS One 12:e0171220. doi:10.1371/journal.pone.0171220.

Koenen K, Knepper I, Klodt M, Osterberg A, Stratos I, Mittlmeier T, Histing T, Menger MD, Vollmar B, Bruhn S, Müller-Hilke B. 2017. Sprint Interval Training Induces A Sexual Dimorphism but does not Improve Peak Bone Mass in Young and Healthy Mice. Sci Rep 7:44047. doi:10.1038/srep44047.

Koslowski N, Sombetzki M, Loebermann M, Engelmann R, Grabow N, Österreicher CH, Trauner M, Mueller-Hilke B, Reisinger EC. 2017. Single-sex infection with female Schistosoma mansoni cercariae mitigates hepatic fibrosis after secondary infection. PLoS Negl Trop Dis 11:e0005595. doi:10.1371/journal.pntd.0005595.

Neumann A-M, Abele J, Kirschstein T, Engelmann R, Sellmann T, Köhling R, Müller-Hilke B. 2017. Mycophenolate mofetil prevents the delayed T cell response after pilocarpine-induced status epilepticus in mice. PLoS One 12:e0187330. doi:10.1371/journal.pone.0187330.

Osterberg A, Thiem D, Herlyn P, Mittlmeier T, Frerich B, Müller-Hilke B. 2017. Subchondral bone sclerosis and cancellous bone loss following OA induction depend on the underlying bone phenotype. Joint Bone Spine 84:71–77. doi:10.1016/j.jbspin.2015.11.012.

Behrendt A-K, Kuhla A, Osterberg A, Polley C, Herlyn P, Fischer D-C, Scotland M, Wree A, Histing T, Menger MD, Müller-Hilke B, Mittlmeier T, Vollmar B. 2016. Dietary Restriction-Induced Alterations in Bone Phenotype: Effects of Lifelong Versus Short-Term Caloric Restriction on Femoral and Vertebral Bone in C57BL/6 Mice. J Bone Miner Res 31:852–863. doi:10.1002/jbmr.2745.

Engelmann R, Biemelt A, Cordshagen A, Johl A, Kuthning D, Müller-Hilke B. 2016. The Prerequisites for Central Tolerance Induction against Citrullinated Proteins in the Mouse. PLoS One 11:e0158773. doi:10.1371/journal.pone.0158773.

Hieke C, Kriebel K, Engelmann R, Müller-Hilke B, Lang H, Kreikemeyer B. 2016. Human dental stem cells suppress PMN activity after infection with the periodontopathogens Prevotella intermedia and Tannerella forsythia. Sci Rep 6:39096. doi:10.1038/srep39096.

Kirschstein T, Wolters A, Lenz J-H, Fröhlich S, Hakenberg O, Kundt G, Darmüntzel M, Hecker M, Altiner A, Müller-Hilke B. 2016. An algorithm for calculating exam quality as a basis for performance-based allocation of funds at medical schools. GMS J Med Educ 33:Doc44. doi:10.3205/zma001043.

Engelmann R, Wang N, Kneitz C, Müller-Hilke B. 2015. Bone resorption correlates with the frequency of CD5⁺ B cells in the blood of patients with rheumatoid arthritis. Rheumatology (Oxford) 54:545–553. doi:10.1093/rheumatology/keu351.

Meister S, Engelmann R, Kneitz C, Müller-Hilke B. 2015. The presence of FCGR2B promoter or transmembrane region variant alleles leads to reduced serum IL-6 levels in rheumatoid arthritis. Rheumatol Int 35:1311–1318. doi:10.1007/s00296-015-3226-0.

Sombetzki M, Fuchs CD, Fickert P, Österreicher CH, Mueller M, Claudel T, Loebermann M, Engelmann R, Langner C, Sahin E, Schwinge D, Guenther ND, Schramm C, Mueller-Hilke B, Reisinger EC, Trauner M. 2015. 24-nor-ursodeoxycholic acid ameliorates inflammatory response and liver fibrosis in a murine model of hepatic schistosomiasis. J Hepatol 62:871–878. doi:10.1016/j.jhep.2014.11.020.

Heun X, Eisenlöffel C, Barann B, Müller-Hilke B. 2014. Dr. med.--obsolete? A cross sectional survey to investigate the perception and acceptance of the German medical degree. GMS Z Med Ausbild 31:Doc30. doi:10.3205/zma000922.

Fritzsche C, Riebold D, Fuehrer A, Mitzner A, Klammt S, Mueller-Hilke B, Reisinger EC. 2013. Pneumocystis jirovecii colonization among renal transplant recipients. Nephrology (Carlton) 18:382–387. doi:10.1111/nep.12054.

Müller-Hilke B. 2013. Leistungsorientierte Mittelvergabe: Mehr Geld zur Lehre lenken. Deutsches Ärzteblatt 110:A-2418-2420.

Pasold J, Engelmann R, Keller J, Joost S, Marshall RP, Frerich B, Müller-Hilke B. 2013. High bone mass in the STR/ort mouse results from increased bone formation and impaired bone resorption and is associated with extramedullary hematopoiesis. J Bone Miner Metab 31:71–81. doi:10.1007/s00774-012-0394-9.

Pasold J, Osterberg A, Peters K, Taipaleenmäki H, Säämänen A-M, Vollmar B, Müller-Hilke B. 2013. Reduced expression of Sfrp1 during chondrogenesis and in articular chondrocytes correlates with osteoarthritis in STR/ort mice. Exp Cell Res 319:649–659. doi:10.1016/j.yexcr.2012.12.012.

Salamon A, Jonitz-Heincke A, Adam S, Rychly J, Müller-Hilke B, Bader R, Lochner K, Peters K. 2013. Articular cartilage-derived cells hold a strong osteogenic differentiation potential in comparison to mesenchymal stem cells in vitro. Exp Cell Res 319:2856–2865. doi:10.1016/j.yexcr.2013.09.008.

Fitzner B, Müller S, Walther M, Fischer M, Engelmann R, Müller-Hilke B, Pützer BM, Kreutzer M, Nizze H, Jaster R. 2012. Senescence determines the fate of activated rat pancreatic stellate cells. J Cell Mol Med 16:2620–2630. doi:10.1111/j.1582-4934.2012.01573.x.

Hilgendorf I, Mueller-Hilke B, Kundt G, Holler E, Hoffmann P, Edinger M, Freund M, Wolff D. 2012. The lack of memory B cells including T cell independent IgM+ IgD+ memory B cells in chronic graft-versus host disease is associated with susceptibility to infection. Transpl Int 25:87–96. doi:10.1111/j.1432-2277.2011.01388.x.

Mueller-Hilke B, Seidl M, Peter H. 2012. Die funktionellen Besonderheiten von IgG4 und die IgG4-assoziierten Krankheiten aus Sicht des Immunologen. Akt Rheumatol 37:288–294. doi:10.1055/s-0032-1314831.

Pohle D, Kasch R, Herlyn P, Bader R, Mittlmeier T, Pützer BM, Müller-Hilke B. 2012. Adenoviral transduction supports matrix expression of alginate cultured articular chondrocytes. Biotechnol Bioeng 109:2402–2408. doi:10.1002/bit.24505.

Jonitz A, Lochner K, Peters K, Salamon A, Pasold J, Mueller-Hilke B, Hansmann D, Bader R. 2011. Differentiation capacity of human chondrocytes embedded in alginate matrix. Connect Tissue Res 52:503–511. doi:10.3109/03008207.2011.593673.

Lochner K, Fritsche A, Jonitz A, Hansmann D, Mueller P, Mueller-Hilke B, Bader R. 2011. The potential role of human osteoblasts for periprosthetic osteolysis following exposure to wear particles. Int J Mol Med 28:1055–1063. doi:10.3892/ijmm.2011.778.

Engelmann R, Eggert M, Neeck G, Mueller-Hilke B. 2010. The impact of HLA-DRB alleles on the subclass titres of antibodies against citrullinated peptides. Rheumatology (Oxford) 49:1862–1866. doi:10.1093/rheumatology/keq179.

Herlyn P, Müller-Hilke B, Wendt M, Hecker M, Mittlmeier T, Gradl G. 2010. Frequencies of polymorphisms in cytokines, neurotransmitters and adrenergic receptors in patients with complex regional pain syndrome type I after distal radial fracture. Clin J Pain 26:175–181. doi:10.1097/AJP.0b013e3181bff8b9.

Müller-Hilke B. 2010. "Ruhm und Ehre" oder LOM für Lehre? - eine qualitative Analyse von Anreizverfahren für gute Lehre an Medizinischen Fakultäten in Deutschland. GMS Zeitschrift für Medizinische Ausbildung; 27(3):Doc43; ISSN 1860-3572. doi:10.3205/zma000680.

Rösler S, Haase T, Claassen H, Schulze U, Schicht M, Riemann D, Brandt J, Wohlrab D, Müller-Hilke B, Goldring MB, Sel S, Varoga D, Garreis F, Paulsen FP. 2010. Trefoil factor 3 is induced during degenerative and inflammatory joint disease, activates matrix metalloproteinases, and enhances apoptosis of articular cartilage chondrocytes. Arthritis Rheum 62:815–825. doi:10.1002/art.27295.

Aminin DL, Koy C, Dmitrenok PS, Müller-Hilke B, Koczan D, Arbogast B, Silchenko AA, Kalinin VI, Avilov SA, Stonik VA, Collin PD, Thiesen H-J, Deinzer ML, Glocker MO. 2009. Immunomodulatory effects of holothurian triterpene glycosides on mammalian splenocytes determined by mass spectrometric proteome analysis. J Proteomics 72:886–906. doi:10.1016/j.jprot.2009.04.004.

Cowell LG, Mitchison NA, Muller B. 2009. Infection and the Diversity of Regulatory DNA, p. 293–306. In Dronamraju KR (ed), Infectious Disease and Host-Pathogen Evolution. Cambridge University Press.

Engelmann R, Müller-Hilke B. 2009. Antikörper gegen citrullinierte Peptidantigene in Klinik und Forschung. Z Rheumatol 68:485–490. doi:10.1007/s00393-009-0494-7.

Engelmann R, Brandt J, Eggert M, Karberg K, Krause A, Neeck G, Mueller-Hilke B. 2009. The anti-mutated citrullinated vimentin response classifies patients with rheumatoid arthritis into broad and narrow responders. J Rheumatol 36:2670–2674. doi:10.3899/jrheum.081263.

Müller-Hilke B. 2009. HLA class II and autoimmunity: epitope selection vs differential expression. Acta Histochem 111:379–381. doi:10.1016/j.acthis.2008.11.011.

Engelmann R, Brandt J, Eggert M, Karberg K, Krause A, Neeck G, Mueller-Hilke B. 2008. IgG1 and IgG4 are the predominant subclasses among auto-antibodies against two citrullinated antigens in RA. Rheumatology (Oxford) 47:1489–1492. doi:10.1093/rheumatology/ken336.

Jaeger K, Selent C, Jaehme W, Mahr S, Goebel U, Ibrahim S, Vollmar B, Mueller-Hilke B. 2008. The genetics of osteoarthritis in STR/ort mice. Osteoarthritis Cartilage 16:607–614. doi:10.1016/j.joca.2007.09.004.

Ruck S, Hilgendorf I, Müller-Hilke B, Kiefel V, Junghanss C, Freund M, Greinix H, Wolff D. 2008. Autoantibody-mediated agranulocytosis in association with chronic GVHD. Bone Marrow Transplant 42:359–360. doi:10.1038/bmt.2008.173.

Doss F, Menard J, Hauschild M, Kreutzer H-J, Mittlmeier T, Müller-Steinhardt M, Müller B. 2007. Elevated IL-6 levels in the synovial fluid of osteoarthritis patients stem from plasma cells. Scand J Rheumatol 36:136–139. doi:10.1080/03009740701250785.

Mahr S, Müller-Hilke B. 2007. Transcriptional activity of the RHOB gene is influenced by regulatory polymorphisms in its promoter region. Genomic Med 1:125–128. doi:10.1007/s11568-007-9012-7.

Müller B, Pavesio C, Eggert M, Neek G, Mitchison N. 2007. Mitigating selection in HLA-B27 not confirmed. Int J Immunogenet 34:431–433. doi:10.1111/j.1744-313X.2007.00717.x.

Müller-Hilke B. 2007. Zur Pathogenese der Arthrose--eine Momentaufnahme. Z Rheumatol 66:703–705. doi:10.1007/s00393-007-0235-8.

Hebel K, Griewank K, Inamine A, Chang H-D, Müller-Hilke B, Fillatreau S, Manz RA, Radbruch A, Jung S. 2006. Plasma cell differentiation in T-independent type 2 immune responses is independent of CD11c(high) dendritic cells. Eur J Immunol 36:2912–2919. doi:10.1002/eji.200636356.

Krenn V, Morawietz L, Burmester G-R, Kinne RW, Mueller-Ladner U, Muller B, Haupl T. 2006. Synovitis score: discrimination between chronic low-grade and high-grade synovitis. Histopathology 49:358–364. doi:10.1111/j.1365-2559.2006.02508.x.

Mahr S, Burmester G-R, Hilke D, Göbel U, Grützkau A, Häupl T, Hauschild M, Koczan D, Krenn V, Neidel J, Perka C, Radbruch A, Thiesen H-J, Müller B. 2006. Cis- and trans-acting gene regulation is associated with osteoarthritis. Am J Hum Genet 78:793–803. doi:10.1086/503849.

Müller-Hilke B, Mitchison NA. 2006. The role of HLA promoters in autoimmunity. Curr Pharm Des 12:3743–3752. doi:10.2174/138161206778559759.

Ma N, Stamm C, Kaminski A, Li W, Kleine H-D, Müller-Hilke B, Zhang L, Ladilov Y, Egger D, Steinhoff G. 2005. Human cord blood cells induce angiogenesis following myocardial infarction in NOD/scid-mice. Cardiovasc Res 66:45–54. doi:10.1016/j.cardiores.2004.12.013.

Müller-Steinhardt M, Fricke L, Müller B, Ebel B, Kirchner H, Härtel C. 2004. Cooperative influence of the interleukin-6 promoter polymorphisms -597, -572 and -174 on long-term kidney allograft survival. Am J Transplant 4:402–406. doi:10.1111/j.1600-6143.2004.00356.x.

Cowell, Linsay G., Mitchison, N.Avrion, Muller, Brigitte, Smith, Laurie G. and Terrazzini, N. 2003. Gene Birth, Death, Modification, Poaching, Crippling, Dimorphism and Culling: The Challenge for Genomics. Proceedings of the Indian National Science Academy 69:447–452.

Heldt C, Listing J, Sözeri O, Bläsing F, Frischbutter S, Müller B. 2003. Differential expression of HLA class II genes associated with disease susceptibility and progression in rheumatoid arthritis. Arthritis Rheum 48:2779–2787. doi:10.1002/art.11251.

Mahr S, Menard J, Krenn V, Müller B. 2003. Sexual dimorphism in the osteoarthritis of STR/ort mice may be linked to articular cytokines. Ann Rheum Dis 62:1234–1237. doi:10.1136/ard.2002.005041.

Moos V, Menard J, Sieper J, Sparmann M, Müller B. 2002. Association of HLA-DRB1*02 with osteoarthritis in a cohort of 106 patients. Rheumatology (Oxford) 41:666–669. doi:10.1093/rheumatology/41.6.666.

Müller B. 2002. Cytokine imbalance in non-immunological chronic disease. Cytokine 18:334–339. doi:10.1006/cyto.2002.0882.

Müller-Steinhardt M, Härtel C, Müller B, Kirchner H, Fricke L. 2002. The interleukin-6 -174promoter polymorphism is associated with long-term kidney allograft survival. Kidney Int 62:1824–1827. doi:10.1046/j.1523-1755.2002.00609.x.

Moos V, Sieper J, Herzog V, Müller B. 2001. Regulation of expression of cytokines and growth factors in osteoarthritic cartilage explants. Clin Rheumatol 20:353–358. doi:10.1007/s100670170025.

Listing J, Rau R, Müller B, Alten R, Gromnica-Ihle E, Hagemann D, Zink A. 2000. HLA-DRB1 genes, rheumatoid factor, and elevated C-reactive protein: independent risk factors of radiographic progression in early rheumatoid arthritis. Berlin Collaborating Rheumatological Study Group. J Rheumatol 27:2100–2109.

Mitchison NA, Muller B, Segal RM. 2000. Natural variation in immune responsiveness, with special reference to immunodeficiency and promoter polymorphism in class II MHC genes. Hum Immunol 61:177–181. doi:10.1016/s0198-8859(99)00141-x.

Moos V, Rudwaleit M, Herzog V, Höhlig K, Sieper J, Müller B. 2000. Association of genotypes affecting the expression of interleukin-1beta or interleukin-1 receptor antagonist with osteoarthritis. Arthritis Rheum 43:2417–2422. doi:10.1002/1529-0131(200011)43:11<2417:AID-ANR7>3.0.CO;2-R.

Czerwony G, Alten R, Gromnica-Ihle E, Hagemann D, Reuter U, Sörensen H, Müller B. 1999. Differential surface expression of HLA-DRB1 and HLA-DRB4 among peripheral blood cells of DR4 positive individuals. Hum Immunol 60:1–9. doi:10.1016/s0198-8859(98)00096-2.

Mitchison NA, Schuhbauer D, Müller B. 1999. Natural and induced regulation of Th1/Th2 balance. Springer Semin Immunopathol 21:199–210. doi:10.1007/BF00812253.

Moos V, Fickert S, Müller B, Weber U, Sieper J. 1999. Immunohistological analysis of cytokine expression in human osteoarthritic and healthy cartilage. J Rheumatol 26:870–879.

Baumgart M, Moos V, Schuhbauer D, Müller B. 1998. Differential expression of major histocompatibility complex class II genes on murine macrophages associated with T cell cytokine profile and protective/suppressive effects. Proc Natl Acad Sci U S A 95:6936–6940. doi:10.1073/pnas.95.12.6936.

Müller B, Gimsa U, Mitchison NA, Radbruch A, Sieper J, Yin Z. 1998. Modulating the Th1/Th2 balance in inflammatory arthritis. Springer Semin Immunopathol 20:181–196. doi:10.1007/BF00832006.

Müller B, Mitchison A. 1997. The importance of the back-signal from T cells into antigen-presenting cells in determining susceptibility to parasites. Philos Trans R Soc Lond B Biol Sci 352:1327–1330. doi:10.1098/rstb.1997.0117.

Baumgart M, Witt C, Hüge W, Müller B. 1996. Increase in the expression of alpha E beta 7, characteristic of intestinal intraepithelial lymphocytes, on T cells in the lung epithelium of patients with interstitial lung diseases and in synovial fluid of patients with rheumatic diseases. Immunobiology 196:415–424. doi:10.1016/s0171-2985(96)80063-5.

Daser A, Mitchison H, Mitchison A, Müller B. 1996. Non-classical-MHC genetics of immunological disease in man and mouse. The key role of pro-inflammatory cytokine genes. Cytokine 8:593–597. doi:10.1006/cyto.1996.0079.

Schuhbauer D, Müller B, Mitchison A. 1996. Unrepresentative behavior of T cell receptor-transgenic CD4+ T cells upon adoptive transfer: lack of need for priming and an extended booster dose-response. Immunobiology 195:152–159. doi:10.1016/S0171-2985(96)80035-0.

Exley M, Wileman T, Mueller B, Terhorst C. 1995. Evidence for multivalent structure of T-cell antigen receptor complex. Mol Immunol 32:829–839. doi:10.1016/0161-5890(95)00046-h.

Müller B, Cooper L, Terhorst C. 1995. Interplay between the human TCR/CD3 epsilon and the B-cell antigen receptor associated Ig-beta (B29). Immunol Lett 44:97–103. doi:10.1016/0165-2478(94)00199-2.

Müller B, Cooper L, Terhorst C. 1994. Molecular cloning of the human homologue to the pig protein-tyrosine kinase syk. Immunogenetics 39:359–362. doi:10.1007/BF00189234.

Terhorst C, Exley M, Franco R, Hall C, Kang J, Mueller B, Sancho J, She J, Wileman T. 1993. Coupling of T-cell activation with T-cell receptor assembly. Year Immunol 7:1–24.

Müller B, Cooper L, Terhorst C. 1992. Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29. Eur J Immunol 22:1621–1625. doi:10.1002/eji.1830220641.

Müller B, Stappert H, Reth M. 1990. A physical map and analysis of the murine C kappa-RS region show the presence of a conserved element. Eur J Immunol 20:1409–1411. doi:10.1002/eji.1830200631.

Klein A, Allmansberger R, Bokranz M, Knaub S, Müller B, Muth E. 1988. Comparative analysis of genes encoding methyl coenzyme M reductase in methanogenic bacteria. Mol Gen Genet 213:409–420. doi:10.1007/BF00339610.

Müller B, Reth M. 1988. Ordered activation of the Ig lambda locus in Abelson B cell lines. J Exp Med 168:2131–2137. doi:10.1084/jem.168.6.2131.

Allmansberger R, Bollschweiler C, Konheiser U, Müller B, Muth E, Pasti G, Klein A. 1986. Arrangement and expression of methyl com reductase genes in Methanococcus voltae. Systematic and Applied Microbiology 7:13–17. doi:10.1016/S0723-2020(86)80117-5.

Müller B, Allmansberger R, Klein A. 1985. Termination of a transcription unit comprising highly expressed genes in the archaebacterium Methanococcus voltae. Nucleic Acids Res 13:6439–6445. doi:10.1093/nar/13.18.6439.