Publikationen der Core Facility

  • Individually or as a Team—The Immunological Milieu in the Lung Caused by Migrating Single-Sex or Mixed-Sex Larvae of Schistosoma mansoni.
    Bischofsberger M, Reinholdt C, Dannenhaus TA, Aleith J, Bergmann-Ewert W, Müller-Hilke B, Löbermann M, Reisinger EC, Sombetzki M: Pathogens. 2023; 12(12):1432.

  • The varying extent of humoral and Th1 immune responses to either vector- or RNA-based SARS-CoV-2 vaccines persists for at least 18 months and is independent of infection.
    Mai F, Bergmann-Ewert W, Müller-Hilke B: re-submitted to Journal of Virology

  • Prophylaxis with abemaciclib delays tumorigenesis in dMMR mice by altering immune responses and reducing immunesuppressive extracellular vesicle secretion.
    Wolff A, Krone P, Maennicke J, Henne J, Oehmcke-Hecht S, Redwanz C, Bergmann-Ewert W,  Junghanss C, Henze L, Maletzki C: submitted to eBioMedicine

  • Combined inhibition of EZH2 and CDK4/6 induces cell stress and enhances antitumor effects against glioblastoma via mitochondrial dysfunction.
    Freitag T, Kaps P, Ramtke J, Wolff A, Bertels S, Zunke E, Schneider B, Becker A-S, Koczan D, Dubinski D, Freiman T, Wittig F, Hinz B, Westhoff M-A, Strobel H, Meiners F, Wolter D, Engel N, Troschke-Meurer S, Bergmann-Ewert W, Maletzki C: manuscript for Cancer Research

  • Establishing safe high hydrostatic pressure devitalization thresholds for autologous head and neck cancer vaccination and reconstruction.
    Maletzki C, Freiin Grote V, Kalle F, Kleitke T, Zimpfer A, Becker AS, Bergmann-Ewert W, Jonitz-Heincke A, Bader R, Vollmar B, Hackenberg S, Scherzad A, Mlynski R, Strüder D. Cell Death Discov. 2023 Oct 23;9(1):390. doi: 10.1038/s41420-023-01671-z. PMID: 37872173; PMCID: PMC10593744.

  • CCR2 macrophage response determines the functional outcome following cardiomyocyte transplantation.
    Vasudevan P, Wolfien M, Lemcke H, Lang CI, Skorska A, Gaebel R, Galow AM, Koczan D, Lindner T, Bergmann W, Mueller-Hilke B, Vollmar B, Krause BJ, Wolkenhauer O, Steinhoff G, David R. Genome Med. 2023 Aug 10;15(1):61. doi: 10.1186/s13073-023-01213-3. PMID: 37563727.

  • Transcriptome alterations in peripheral blood B cells of patients with multiple sclerosis receiving immune reconstitution therapy.
    Hecker M, Fitzner B, Boxberger N, Putscher E, Engelmann R, Bergmann W, Müller M, Ludwig-Portugall I, Schwartz M, Meister S, Dudesek A, Winkelmann A, Koczan D, Zettl K U. . J Neuroinflammation. 2023 Aug 2;20(1):181. doi: 10.1186/s12974-023-02859-x. PMID: 37533036; PMCID: PMC10394872.

  • Short-term immune-checkpoint inhibition partially rescues perturbed bone marrow hematopoiesis in mismatch-repair deficient tumors.
    Krone P, Wolff A, Teichmann J, Maennicke J, Henne J, Engster L, Salewski I, Bergmann W, Junghanss C, Maletzki C. Oncoimmunology. 2023 Jun 28;12(1):2230669. doi: 10.1080/2162402X.2023.2230669. PMID: 37396958; PMCID: PMC10312035.

  • The addition of arginine deiminase potentiates Mithramycin A-induced cell death in patient-derived glioblastoma cells via ATF4 and cytochrome C.
    Linke C, Freitag T, Riess C, Scheffler JV, Del Moral K, Schoenwaelder N, Fiedler T, Fiebig A, Kaps P, Dubinski D, Schneider B, Bergmann W, Classen CF, Maletzki C. Cancer Cell Int. 2023 Feb 27;23(1):38. doi: 10.1186/s12935-023-02873-2. PMID: 36843002; PMCID: PMC9969664.

  • The role of CD5+ B cells in periodontal diseases - An immunological and microbiological investigation Gottschalk, EC, Chabanovska, O, Vasudevan, P, Barrantes, I, Kreikemeyer, B, Bergmann W, Engelmann R, Müller-Hilke B, Lang H. Journal of Clinical Periodontology. [ submitted ]
  • CDK4/6 blockade provides an alternative approach for treatment of mismatch-repair deficient tumors.
    Salewski I, Henne J, Engster L, Krone P, Schneider B, Redwanz C, Lemcke H, Henze L, Junghanss C, Maletzki C. Oncoimmunology. 2022 Jul 11;11(1):2094583. doi: 10.1080/2162402X.2022.2094583. PMID: 35845723; PMCID: PMC9278458.
  • Distinguishing Incubation and Acute Disease Stages of Mild-to-Moderate COVID-19.
    Müller M, Volzke J, Subin B, Schmidt CJ, Geerdes-Fenge H, Reisinger EC, Müller-Hilke B. Viruses. 2022 Jan 20;14(2):203. doi: 10.3390/v14020203. PMID: 35215797; PMCID: PMC8875077.
  • Vaccine-Induced T-Cell and Antibody Responses at 12 Months after Full Vaccination Differ with Respect to Omicron Recognition.
    Mai F, Volzke J, Reisinger EC, Müller-Hilke B. Vaccines (Basel). 2022 Sep 19;10(9):1563. doi: 10.3390/vaccines10091563. PMID: 36146641; PMCID: PMC9500953.
  • Single-dose SARS-CoV-2 vaccinations with either BNT162b2 or AZD1222 induce disparate Th1 responses and IgA production.
    Müller M, Volzke J, Subin B, Müller S, Sombetzki M, Reisinger EC, Müller-Hilke B. BMC Med. 2022 Jan 19;20(1):29. doi: 10.1186/s12916-022-02240-4. PMID: 35042529; PMCID: PMC8766223.
  • Higher SARS-CoV-2 Spike Binding Antibody Levels and Neutralization Capacity 6 Months after Heterologous Vaccination with AZD1222 and BNT162b2.
    Müller-Hilke B, Mai F, Müller M, Volzke J, Reisinger EC. Vaccines (Basel). 2022 Feb 17;10(2):322. doi: 10.3390/vaccines10020322. PMID: 35214780; PMCID: PMC8880180.
  • Influenza A Virus Exacerbates Group A Streptococcus Infection and Thwarts Anti-Bacterial Inflammatory Responses in Murine Macrophages.
    Aleith J, Brendel M, Weipert E, Müller M, Schultz D, Ko-Infekt Study Group, Müller-Hilke B. Pathogens. 2022 Nov 10;11(11):1320. doi: 10.3390/pathogens11111320. PMID: 36365071; PMCID: PMC9699311.
  • Spontaneous Hind Limb Paralysis Due to Acute Precursor B Cell Leukemia in RAG1-deficient Mice.
    Feifei L, Richter A, Runge J, Keiler J, Hermann A, Kipp M, Joost S. J Mol Neurosci. 2022 Aug;72(8):1646-1655. doi: 10.1007/s12031-022-02025-7. Epub 2022 May 18. PMID: 35583713; PMCID: PMC9374608.
  • Highly Potent and Selective Antitumor Agents Evolved from Iterative Structure Optimization.
    Eichhorst A, Gallhof M, Voss A, Sekora A, Eggers L, Huyen LT, Junghanss C, Murua Escobar H, Brasholz M. Spirooxindol-1,3-oxazine Alkaloids: ChemMedChem. 2022 Jul 19;17(14):e202200162. doi: 10.1002/cmdc.202200162. Epub 2022 May 23. PMID: 35491398; PMCID: PMC9400852.
  • The Inhibitory Response to PI3K/AKT Pathway Inhibitors MK-2206 and Buparlisib Is Related to Genetic Differences in Pancreatic Ductal Adenocarcinoma Cell Lines.
    Ma Y, Sender S, Sekora A, Kong W, Bauer P, Ameziane N, Al-Ali R, Krake S, Radefeldt M, Weiss FU, Lerch MM, Parveen A, Zechner D, Junghanss C, Murua Escobar H. Int J Mol Sci. 2022 Apr 13;23(8):4295. doi: 10.3390/ijms23084295. PMID: 35457111; PMCID: PMC9029322.
  • Inhibitory Response to CK II Inhibitor Silmitasertib and CDKs Inhibitor Dinaciclib Is Related to Genetic Differences in Pancreatic Ductal Adenocarcinoma Cell Lines.
    Ma Y, Sender S, Sekora A, Kong W, Bauer P, Ameziane N, Krake S, Radefeldt M, Al-Ali R, Weiss FU, Lerch MM, Parveen A, Zechner D, Junghanss C, Murua Escobar H. Int J Mol Sci. 2022 Apr 16;23(8):4409. doi: 10.3390/ijms23084409. PMID: 35457227; PMCID: PMC9031017.
  • Genetic risk variants for multiple sclerosis are linked to differences in alternative pre-mRNA splicing.
    Putscher E, Hecker M, Fitzner B, Boxberger N, Schwartz M, Koczan D, Lorenz P, Zettl UK. Front Immunol. 2022 Oct 28;13:931831. doi: 10.3389/fimmu.2022.931831. PMID: 36405756; PMCID: PMC9670805.
  • Implication of genetic variants in primary microRNA processing sites in the risk of multiple sclerosis.
    Hecker M, Fitzner B, Putscher E, Schwartz M, Winkelmann A, Meister S, Dudesek A, Koczan D, Lorenz P, Boxberger N, Zettl UK. EBioMedicine. 2022 Jun;80:104052. doi: 10.1016/j.ebiom.2022.104052. Epub 2022 May 10. PMID: 35561450; PMCID: PMC9111935.
  • Cuprizone-induced demyelination triggers a CD8-pronounced T cell recruitment.
    Kaddatz H, Joost S, Nedelcu J, Chrzanowski U, Schmitz C, Gingele S, Gudi V, Stangel M, Zhan J, Santrau E, Greiner T, Frenz J, Müller-Hilke B, Müller M, Amor S, van der Valk P, Kipp M. Glia. 2021 Apr;69(4):925-942. doi: 10.1002/glia.23937. Epub 2020 Nov 27. PMID: 33245604.
  • The Individual Effects of Cyclin-Dependent Kinase Inhibitors on Head and Neck Cancer Cells-A Systematic Analysis.
    Schoenwaelder N, Salewski I, Engel N, Krause M, Schneider B, Müller M, Riess C, Lemcke H, Skorska A, Grosse-Thie C, Junghanss C, Maletzki C. Cancers (Basel). 2021 May 15;13(10):2396. doi: 10.3390/cancers13102396. PMID: 34063457; PMCID: PMC8157193.  
  • Combined Gemcitabine and Immune-Checkpoint Inhibition Conquers Anti-PD-L1 Resistance in Low-Immunogenic Mismatch Repair-Deficient Tumors.
    Salewski I, Henne J, Engster L, Schneider B, Lemcke H, Skorska A, Berlin P, Henze L, Junghanss C, Maletzki C. Int J Mol Sci. 2021 Jun 1;22(11):5990. doi: 10.3390/ijms22115990. PMID: 34206051; PMCID: PMC8199186.
  • Infection With Clostridioides difficile Attenuated Collagen-Induced Arthritis in Mice and Involved Mesenteric Treg and Th2 Polarization.
    Schmidt CJ, Wenndorf K, Ebbers M, Volzke J, Müller M, Strübing J, Kriebel K, Kneitz S, Kreikemeyer B, Müller-Hilke B. Front Immunol. 2020 Oct 30;11:571049. doi: 10.3389/fimmu.2020.571049. PMID: 33193352; PMCID: PMC7662472.
  • Cardiomyocyte Transplantation after Myocardial Infarction Alters the Immune Response in the Heart.
    Vasudevan P, Wolfien M, Lemcke H, Lang CI, Skorska A, Gaebel R, Koczan D, Lindner T, Engelmann R, Vollmar B, Krause BJ, Wolkenhauer O, Lang H, Steinhoff G, David R. Cells. 2020 Aug 3;9(8):1825. doi: 10.3390/cells9081825. PMID: 32756334; PMCID: PMC7465503.
  • Inflammatory Joint Disease Is a Risk Factor for Streptococcal Sepsis and Septic Arthritis in Mice.
    Volzke J, Schultz D, Kordt M, Müller M, Bergmann W, Methling K, Kreikemeyer B, Müller-Hilke B; KoInfekt Study Group. Front Immunol. 2020 Oct 7;11:579475. doi: 10.3389/fimmu.2020.579475. PMID: 33117382; PMCID: PMC7576673.
  • Periodontal pathogens do not exacerbate macroscopic arthritis but alter the synovial proteome in mice.
    Buschhart AL, Bolten L, Volzke J, Ekat K, Kneitz S, Mikkat S, Kreikemeyer B, Müller-Hilke B. Periodontal pathogens alter the synovial proteome. PLoS One. 2020 Dec 31;15(12):e0242868. doi: 10.1371/journal.pone.0242868. PMID: 33382721; PMCID: PMC7774964.
  • Albumin promotes proliferation of G1 arrested serum starved hepatocellular carcinoma cells.
    Ibrahim B, Stange J, Dominik A, Sauer M, Doss S, Eggert M. PeerJ. 2020 Mar 5;8:e8568. doi: 10.7717/peerj.8568. PMID: 32185103; PMCID: PMC7060934.
  • Preventive CTLA-4-Ig Treatment Reduces Hepatic Egg Load and Hepatic Fibrosis in Schistosoma mansoni-Infected Mice.
    Sombetzki M, Rabes A, Bischofsberger M, Winkelmann F, Koslowski N, Schulz C, Reisinger EC. Biomed Res Int. 2019 Dec 16;2019:1704238. doi: 10.1155/2019/1704238. PMID: 31950032; PMCID: PMC6948272.
  • Periodontal treatment prevents arthritis in mice and methotrexate ameliorates periodontal bone loss.
    Lübcke PM, Ebbers MNB, Volzke J, Bull J, Kneitz S, Engelmann R, Lang H, Kreikemeyer B, Müller-Hilke B. Sci Rep. 2019 May 31;9(1):8128. doi: 10.1038/s41598-019-44512-9. PMID: 31148565; PMCID: PMC6544621.
  • Human adipocytes and CD34+ cells from the stromal vascular fraction of the same adipose tissue differ in their energy metabolic enzyme configuration.
    Meyer J, Engelmann R, Kamp G, Peters K. Exp Cell Res. 2019 Jul 1;380(1):47-54. doi: 10.1016/j.yexcr.2019.04.018. Epub 2019 Apr 16. PMID: 31002814.
  • Generation of the Niemann-Pick type C2 patient-derived iPSC line AKOSi001-A.
    Völkner C, Peter F, Liedtke M, Krohn S, Lindner I, Murua Escobar H, Cimmaruta C, Lukas J, Hermann A, Frech MJ. Stem Cell Res. 2019 Dec;41:101606. doi: 10.1016/j.scr.2019.101606. Epub 2019 Oct 15. PMID: 31669975.
  • A therapy with miglustat, 2-hydroxypropyl-ß-cyclodextrin and allopregnanolone restores splenic cholesterol homeostasis in Niemann-pick disease type C1.
    Neßlauer AM, Gläser A, Gräler M, Engelmann R, Müller-Hilke B, Frank M, Burstein C, Rolfs A, Neidhardt J, Wree A, Witt M, Bräuer AU. Lipids Health Dis. 2019 Jun 28;18(1):146. doi: 10.1186/s12944-019-1088-2. PMID: 31248418; PMCID: PMC6598286.
  • A novel method to efficiently isolate medullary thymic epithelial cells from murine thymi based on UEA-1 MicroBeads.
    Dohr D, Engelmann R, Müller-Hilke B. J Immunol Methods. 2019 Apr;467:12-18. doi: 10.1016/j.jim.2019.02.001. Epub 2019 Feb 5. PMID: 30735690.
  • Host Defense Versus Immunosuppression: Unisexual Infection With Male or Female Schistosoma mansoni Differentially Impacts the Immune Response Against Invading Cercariae.
    Sombetzki M, Koslowski N, Rabes A, Seneberg S, Winkelmann F, Fritzsche C, Loebermann M, Reisinger EC. Front Immunol. 2018 Apr 24;9:861. doi: 10.3389/fimmu.2018.00861. PMID: 29743881; PMCID: PMC5930291.
  • Interplay between P. gingivalis, F. nucleatum and A. actinomycetemcomitans in murine alveolar bone loss, arthritis onset and progression.
    Ebbers M, Lübcke PM, Volzke J, Kriebel K, Hieke C, Engelmann R, Lang H, Kreikemeyer B, Müller-Hilke B. Sci Rep. 2018 Oct 11;8(1):15129. doi: 10.1038/s41598-018-33129-z. PMID: 30310087; PMCID: PMC6181973.
  • Adoptive transfer of CD3+ T cells and CD4+ CD44high memory T cells induces autoimmune pancreatitis in MRL/MpJ mice.
    Ehlers L, Rohde S, Ibrahim S, Jaster R. J Cell Mol Med. 2018 Apr;22(4):2404-2412. doi: 10.1111/jcmm.13537. Epub 2018 Jan 31. PMID: 29383850; PMCID: PMC5867153.
  • Intramyocardial angiogenetic stem cells and epicardial erythropoietin save the acute ischemic heart.
    Klopsch C, Skorska A, Ludwig M, Lemcke H, Maass G, Gaebel R, Beyer M, Lux C, Toelk A, Müller K, Maschmeier C, Rohde S, Mela P, Müller-Hilke B, Jockenhoevel S, Vollmar B, Jaster R, David R, Steinhoff G. Dis Model Mech. 2018 Jun 22;11(6):dmm033282. doi: 10.1242/dmm.033282. PMID: 29752300; PMCID: PMC6031356.
  • Decreased IgG4 ACPA levels in responders and increased CD1c+ classical dendritic cells in non-responders of patients with rheumatoid arthritis under therapy.
    Engelmann R, Nekarda S, Kuthning D, Kneitz C, Müller-Hilke B. Clin Rheumatol. 2018 Jul;37(7):1783-1790. doi: 10.1007/s10067-018-4053-y. Epub 2018 Mar 3. PMID: 29502227.
  • Reduced Numbers of Mature Medullary Thymic Epithelial Cells in SKG Mice.
    Engelmann R, Biemelt A, Johl A, Kuthning D, Müller-Hilke B. Scand J Immunol. 2018 Jan;87(1):28-35. doi: 10.1111/sji.12626. Epub 2017 Dec 4. PMID: 29105157.
  • Porphyromonas gingivalis Peptidyl Arginine Deiminase Can Modulate Neutrophil Activity via Infection of Human Dental Stem Cells.
    Kriebel K, Hieke C, Engelmann R, Potempa J, Müller-Hilke B, Lang H, Kreikemeyer B. J Innate Immun. 2018;10(4):264-278. doi: 10.1159/000489020. Epub 2018 Jun 1. PMID: 29860256; PMCID: PMC6158109.
  • Mycophenolate mofetil prevents the delayed T cell response after pilocarpine-induced status epilepticus in mice.
    Neumann AM, Abele J, Kirschstein T, Engelmann R, Sellmann T, Köhling R, Müller-Hilke B. PLoS One. 2017 Nov 28;12(11):e0187330. doi: 10.1371/journal.pone.0187330. PMID: 29182639; PMCID: PMC5705158.
  • Experimental silicosis does not aggravate collagen-induced arthritis in mice.
    Engelmann R, Müller-Hilke B. J Negat Results Biomed. 2017 Mar 13;16(1):5. doi: 10.1186/s12952-017-0071-6. PMID: 28285600; PMCID: PMC5346855.
  • The Prerequisites for Central Tolerance Induction against Citrullinated Proteins in the Mouse.
    Engelmann R, Biemelt A, Cordshagen A, Johl A, Kuthning D, Müller-Hilke B. PLoS One. 2016 Jun 30;11(6):e0158773. doi: 10.1371/journal.pone.0158773. PMID: 27362943; PMCID: PMC4928850.
  • In vitro studies implicate an imbalanced activation of dendritic cells in the pathogenesis of murine autoimmune pancreatitis.
    Borufka L, Volmer E, Müller S, Engelmann R, Nizze H, Ibrahim S, Jaster R. Oncotarget. 2016 Jul 12;7(28):42963-42977. doi: 10.18632/oncotarget.10265. PMID: 27356751; PMCID: PMC5190000.
  • The presence of FCGR2B promoter or transmembrane region variant alleles leads to reduced serum IL-6 levels in rheumatoid arthritis.
    Meister S, Engelmann R, Kneitz C, Müller-Hilke B. Rheumatol Int. 2015 Aug;35(8):1311-8. doi: 10.1007/s00296-015-3226-0. Epub 2015 Jan 29. PMID: 25630523.
  • Bone resorption correlates with the frequency of CD5⁺ B cells in the blood of patients with rheumatoid arthritis.
    Engelmann R, Wang N, Kneitz C, Müller-Hilke B. Rheumatology (Oxford). 2015 Mar;54(3):545-53. doi: 10.1093/rheumatology/keu351. Epub 2014 Sep 5. PMID: 25193807.
  • Glatiramer acetate treatment effects on gene expression in monocytes of multiple sclerosis patients.
    Thamilarasan M, Hecker M, Goertsches RH, Paap BK, Schröder I, Koczan D, Thiesen HJ, Zettl UK. J Neuroinflammation. 2013 Oct 17;10:126. doi: 10.1186/1742-2094-10-126. PMID: 24134771; PMCID: PMC3852967.
  • Senescence determines the fate of activated rat pancreatic stellate cells.
    Fitzner B, Müller S, Walther M, Fischer M, Engelmann R, Müller-Hilke B, Pützer BM, Kreutzer M, Nizze H, Jaster R. J Cell Mol Med. 2012 Nov;16(11):2620-30. doi: 10.1111/j.1582-4934.2012.01573.x. PMID: 22452900; PMCID: PMC4118230.
  • The lack of memory B cells including T cell independent IgM+ IgD+ memory B cells in chronic graft-versus host disease is associated with susceptibility to infection.
    Hilgendorf I, Mueller-Hilke B, Kundt G, Holler E, Hoffmann P, Edinger M, Freund M, Wolff D. Transpl Int. 2012 Jan;25(1):87-96. doi: 10.1111/j.1432-2277.2011.01388.x. Epub 2011 Nov 21. PMID: 22098606.